Assistant Professor Director, Statistical Consulting Center Department of Bioinformatics and Biostatistics School of Public Health and Information Sciences University of Louisville Louisville, KY 40292 Email: guy.brock@louisville.edu Phone: (502) 852-3444 Fax: (502) 852-3294

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My methodological focus is in the area of bioinformatics and statistical genetics. Currently, I am working selection methods for imputation algorithms in microarray data, cluster validation, and empirical methods for evaluating the number of markers needed for inferring ancestry in a study population. We are currently forming a Bioinformatics Working Group withing our department, along with fellow faculty members Somnath Datta and Susmita Datta. I also have significant collaborations with the departments of Epidemiology and Public Health, Pharmacology and Toxicology, Molecular, Cellular, and Craniofacial Biology, and Infectious Disease.

Publications

• Brock, G.N. , Shaffer, J.R., Blakesley-Ball, R.E., Lotz, M.J., and Tseng, G.C. (2008) "Which missing value imputation method to use in expression profiles: a comparative study and two selection schemes" BMC Bioinformatics 9:12
• Brock, G.N. , Weeks, D.E., Sobel, E. and Feingold, E. (2007) "A novel method for estimating significance levels in NPL scores for large pedigrees" Genet Epi. 31(5):417-430
• Brock, G.N. , Pihur, V., Datta, S., and Datta, S. (2007) "clValid, an R package for cluster validation" (accepted subject to minor revision by Journal Statistical Software )
• Brock, G.N. , Beavis, W., and Salter, L. (2007) "Fuzzy logic and related methods as a screening tool for detecting gene regulatory networks", (accepted by Information Fusion )
• Pihur, V., Brock, G.N. , Datta, S. and Datta, S. "Cluster validation for microarray data: An appraisal". In Indian Statistical Institute Platinum Jubilee Series (A. SenGupta, Ed), World Scientific Press, to appear (2008).
• Bhattacharjee, S., Kuo, C-L., Mukhopadhyay, N., Brock, G.N. , Weeks, D.E., and Feingold, F. (2007) "Robust score statistics for QTL linkage analysis" (accepted by The American Journal of Human Genetics )
• Xu, P., Brock, G.N. , and Parrish, R.S. "Modified linear discriminant analysis approaches for classification of high-dimensional microarray data" (submitted to Computational Statistics and Data Analysis )
• Brock, G.N. , Maher, B.S., Goldstein, T.H., Cooper, M.E., and Marazita, M.L. (2005) "Methods for detecting gene-gene interaction in multiplex extended pedigrees" BMC Genet. 6 Suppl 1:S144.
• Maher, B.S., and Brock, G.N. (2005) "Approaches to detecting epistasis in the genetic analysis workshop 14 Pedigrees" Genet Epi. 29 Suppl 1:S116-9.

Software

• FPRNET Software to accompany the paper by Brock, Beavis, and Salter (2007) "Fuzzy logic and alternate methods for detecting gene regulatory Networks"
• clValid An R package for cluster validation
• Version 0.6 zip file , source code

Collaborators

Somnath Datta (Bioinformatics and Biostatistics, UofL)
Susmita Datta (Bioinformatics and Biostatistics, UofL)
Rudy Parrish (Bioinformatics and Biostatistics, UofL)
Kathy B. Baumgartner (Epidemiology and Population Health, UofL)
Richard N. Baumgartner (Epidemiology and Population Health, UofL)
Robert M. Greene (Molecular, Cellular, and Craniofacial Biology, UofL)
M. Michele Pisano (Molecular, Cellular, and Craniofacial Biology, UofL)
Julio A. Ramirez (Infectious Disease, UofL)
La Creis R. Kidd (Pharmacology and Toxicology, UofL)
Mark Brennan (Biochemistry and Moleculary Biology, UofL)
Eric Rouchka (Computer Science, UofL)
Ted Kalbfleisch (Center for Genetics and Molecular Medicine, UofL)